Our findings may provide interesting insight into the effect of platelet life span and turnover on aspirin resistance. High MPV, commonly due to younger and more aggregable platelets, is associated with arachidonic acid– and collagen‐defined aspirin resistance independent of cardiovascular risk factors and native platelet reactivity. After adjusting for agonist‐specific pre‐ASA platelet aggregation (Figure, lower), MPV remained associated with aspirin resistance as defined by collagen and arachidonic acid but was no longer associated with ADP‐defined aspirin resistance. This association remained significant after adjusting for age, sex, race, hypertension, diabetes, low‐density lipoprotein cholesterol, smoking status, and fibrinogen (Figure, upper). Or it can mean that a condition is causing too many white blood cells to be. It can be a sign of chronic inflammation in your body. In unadjusted analysis, MPV was associated with aspirin resistance as defined by each agonist and dose. An abnormally high basophil level is called basophilia. Mean (SD) age was 45.9 (13.5) years 55% were female 40% African American 25% current smokers, 37% hypertensive, and 12% diabetic. We used logistic regression with adjustment for familial relationship. Evidence proved that platelet activation in dyslipidemia induced CAD, however, their interaction has not been well-established in vivo. High MPV can be observed with a high, low, normal, or variable platelet counts. This indicates that a large number of new cells are released into the circulation by the bone marrow, either to compensate for any excessive breakdown of platelets or to promote healing. For collagen and ADP, individuals in the highest quartile of aggregation after ASA therapy were defined as aspirin resistant. ObjectiveCurrently, coronary artery disease (CAD) is regarded as one of the leading global disease burdens. A high mean platelet volume (MPV) means a larger platelet size. Individuals with any arachidonic acid–mediated aggregation were defined as aspirin resistant. You might also need a procedure that uses a needle to remove a small sample of your bone marrow for testing. You may also need blood tests to check for: High or low iron levels. For each dose of each agonist, we examined the association between MPV and aspirin resistance separately. Diagnosis A blood test called a complete blood count (CBC) can show if your platelet count is too high. As shown in Figure 2 (a,b), the median platelet counts was 9.4 higher in the early foetal demise group than those in the normal delivery group (245 × 10 9 vs. Optical aggregation was measured in platelet‐rich plasma after samples were stimulated with collagen (2 and 5 μg/mL), ADP (2 and 10 μmol/L), or arachidonic acid (1.6 mmol/L) before and after 14 days of ASA therapy. We compared MPV and platelet counts in early foetal demise group with those in the normal delivery group in the 510 weeks’ gestation. Methods:įasting blood samples were obtained from healthy participants ( n = 2363 from 584 families) with a family history of premature coronary artery disease. Our aim was to examine whether individuals with high MPV are more likely to have aspirin resistance. However, a relationship between high MPV and aspirin resistance, as measured by platelet aggregation, has not been reported. Aspirin (ASA) resistance and high mean platelet volume (MPV) are associated with increased risk for cardiovascular events.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |